Deepak Dalvie: search on Z-Library

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1

Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery

Pryde, David C., Dalvie, Deepak, Hu, Qiyue, Jones, Peter, Obach, R. Scott, Tran, Thien-Duc

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 4.29 MB

english, 2010

2

Aldehyde Oxidase and Its Role as a Drug Metabolizing Enzyme

Dalvie, Deepak, Di, Li

Journal:

Pharmacology & Therapeutics

Year:

2019

Language:

english

File:

PDF, 14.96 MB

english, 2019

3

Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB. O-BK) || Pathways of Reactive Metabolite Formation with Toxicophores/-Structural Alerts

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 373 KB

english, 2012

4

Interactions of Nitrogen-Containing Xenobiotics with Monoamine Oxidase (MAO) Isozymes A and B: SAR Studies on MAO Substrates and Inhibitors

Kalgutkar, Amit S., Dalvie, Deepak K., Castagnoli,, Neal, Taylor, Timothy J.

Journal:

Chemical Research in Toxicology

Year:

2001

Language:

english

File:

PDF, 292 KB

english, 2001

5

Design, synthesis, and biological evaluation of novel 4-substituted 1-methyl-1,2,3,6-tetrahydropyridine analogs of MPTP

Zhao, Zhiyang, Dalvie, Deepak, Naiman, Noreen, Castagnoli, Kay, Castagnoli, Neal

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 804 KB

english, 1992

6

Predicting Toxicities of Reactive Metabolite–Positive Drug Candidates

Kalgutkar, Amit S., Dalvie, Deepak

Journal:

Annual Review of Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.01 MB

english, 2015

7

Strategies for a comprehensive understanding of metabolism by aldehyde oxidase

Hutzler, James Matthew, Obach, Ronald Scott, Dalvie, Deepak, Zientek, Michael A

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2013

Language:

english

File:

PDF, 871 KB

english, 2013

8

Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy

Gomes, Bruno, Driessens, Gregory, Bartlett, Derek, Cai, Danying, Cauwenberghs, Sandra, Crosignani, Stefano, Dalvie, Deepak, Denies, Sofie, Dillon, Christopher P, Fantin, Valeria R, Guo, Jie, Letellier

Journal:

Molecular Cancer Therapeutics

Year:

2018

Language:

english

File:

PDF, 3.26 MB

english, 2018

9

Characterization of polar urinary metabolites by ionspray tandem mass spectrometry following dansylation

Deepak K. Dalvie, John P. O’Donnell

Journal:

Rapid Communications in Mass Spectrometry

Year:

1998

Language:

english

File:

PDF, 94 KB

english, 1998

10

Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK

Steven P. Tanis, Michael B. Plewe, Ted W. Johnson, Scott L. Butler, Deepak Dalvie, Dorothy DeLisle, Klaus R. Dress, Qiyue Hu, Buwen Huang, Jon E. Kuehler, Atsuo Kuki, Wen Liu, Qinghai Peng, Graham L.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.54 MB

english, 2010

11

Identification of primary and sequential bioactivation pathways of carbamazepine in human liver microsomes using liquid chromatography/tandem mass spectrometry

Hai-Zhi Bu, Ping Zhao, Deepak K. Dalvie, William F. Pool

Journal:

Rapid Communications in Mass Spectrometry

Year:

2007

Language:

english

File:

PDF, 332 KB

english, 2007

12

Synthesis of 4-(2-chloroethyl)-2,3-dihydro[1,4]oxazino[2,3-b]quinoline and 4-(2-chloroethyl)2,3-dihydropyrido[2,3-b][1,4]oxazine

Wayne K. Anderson, Deepak K. Dalvie

Journal:

Journal of Heterocyclic Chemistry

Year:

1993

File:

PDF, 293 KB

1993

13

Design and Synthesis of Novel N-Hydroxy-Dihydronaphthyridinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors

Hu, Qiyue, Kuehler, Jon E., Kuki, Atsuo, Johnson, Ted W., Tanis, Steven P., Butler, Scott L., Dalvie, Deepak, DeLisle, Dorothy M., Dress, Klaus R., Flahive, Erik J.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.13 MB

english, 2011

14

Myeloperoxidase-mediated bioactivation of 5-hydroxythiabendazole: A possible mechanism of thiabendazole toxicity

Joseph D. Jamieson, Evan B. Smith, Deepak K. Dalvie, Gregory J. Stevens, Gina M. Yanochko

Journal:

Toxicology in Vitro

Year:

2011

Language:

english

File:

PDF, 511 KB

english, 2011

15

Pharmacokinetics and metabolism of single oral doses of trovafloxacin

John Vincent, Renli Teng, Deepak K. Dalvie, Hylar L. Friedman

Journal:

The American Journal of Surgery

Year:

1998

Language:

english

File:

PDF, 183 KB

english, 1998

16

Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB. O-BK) || Bioactivation and Inactivation of Cytochrome P450 and Other Drug-Metabolizing Enzymes

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 307 KB

english, 2012

17

Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB. O-BK) || Role of Reactive Metabolites in Drug-Induced Toxicity - The Tale of Acetaminophen, Halothane, Hydralazine, and Tienilic Acid

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 195 KB

english, 2012

18

Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB. O-BK) || Role of Reactive Metabolites in Genotoxicity

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 532 KB

english, 2012

19

Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB. O-BK) || Retrospective Analysis of Structure-Toxicity Relationships of Drugs

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 184 KB

english, 2012

20

Cytogenetic investigations in couples with repeated miscarriages and malformed children: report of a novel insertion

Priya Iyer, Leena Wani, Smruti Joshi, Jyothi Lakshmi, Rupa Dalvi, Deepak Chavan, Bibhu Ranjan Das, Swarna Mandava

Journal:

Reproductive BioMedicine Online

Year:

2007

Language:

english

File:

PDF, 534 KB

english, 2007

21

Pharmacokinetics and Metabolism of 2-Aminothiazoles with Antiprion Activity in Mice

Silber, B. Michael, Rao, Satish, Fife, Kimberly L., Gallardo-Godoy, Alejandra, Renslo, Adam R., Dalvie, Deepak K., Giles, Kurt, Freyman, Yevgeniy, Elepano, Manuel, Gever, Joel R., Li, Zhe, Jacobson, M

Journal:

Pharmaceutical Research

Year:

2013

Language:

english

File:

PDF, 1.18 MB

english, 2013

22

Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings

Dalvie, Deepak K., Kalgutkar, Amit S., Khojasteh-Bakht, S. Cyrus, Obach, R. Scott, O'Donnell, John P.

Journal:

Chemical Research in Toxicology

Year:

2002

Language:

english

File:

PDF, 447 KB

english, 2002

23

Structure-based design, SAR analysis and antitumor activity of PI3K/mTOR dual inhibitors from 4-methylpyridopyrimidinone series

Cheng, Hengmiao, Hoffman, Jacqui E., Le, Phuong T., Pairish, Mason, Kania, Robert, Farrell, William, Bagrodia, Shubha, Yuan, Jing, Sun, Shaoxian, Zhang, Eric, Xiang, Cathy, Dalvie, Deepak, Rahavendran

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.03 MB

english, 2013

24

Assessment of Three Human in Vitro Systems in the Generation of Major Human Excretory and Circulating Metabolites

Dalvie, Deepak, Obach, R. Scott, Kang, Ping, Prakash, Chandra, Loi, Cho-Ming, Hurst, Susan, Nedderman, Angus, Goulet, Lance, Smith, Evan, Bu, Hai-Zhi, Smith, Dennis A.

Journal:

Chemical Research in Toxicology

Year:

2009

Language:

english

File:

PDF, 657 KB

english, 2009

25

Effect of Intestinal Glucuronidation in Limiting Hepatic Exposure and Bioactivation of Raloxifene in Humans and Rats

Dalvie, Deepak, Kang, Ping, Zientek, Michael, Xiang, Cathie, Zhou, Sue, Obach, R. Scott

Journal:

Chemical Research in Toxicology

Year:

2008

Language:

english

File:

PDF, 1.12 MB

english, 2008

26

Bioactivation of Lumiracoxib by Peroxidases and Human Liver Microsomes: Identification of Multiple Quinone Imine Intermediates and GSH Adducts

Kang, Ping, Dalvie, Deepak, Smith, Evan, Renner, Matt

Journal:

Chemical Research in Toxicology

Year:

2009

Language:

english

File:

PDF, 323 KB

english, 2009

27

The Generation, Detection, and Effects of Reactive Drug Metabolites

Stachulski, Andrew V., Baillie, Thomas A., Kevin Park, B., Scott Obach, R., Dalvie, Deepak K., Williams, Dominic P., Srivastava, Abhishek, Regan, Sophie L., Antoine, Daniel J., Goldring, Christopher E

Journal:

Medicinal Research Reviews

Year:

2013

Language:

english

File:

PDF, 2.07 MB

english, 2013

28

Interspecies variation in the metabolism of zoniporide by aldehyde oxidase

Dalvie, Deepak, Xiang, Cathie, Kang, Ping, Zhou, Sue

Journal:

Year:

2013

Language:

english

File:

PDF, 1.33 MB

english, 2013

29

Drug discovery for a new generation of covalent drugs

Kalgutkar, Amit S, Dalvie, Deepak K

Journal:

Expert Opinion on Drug Discovery

Year:

2012

Language:

english

File:

PDF, 707 KB

english, 2012

30

NADPH-Dependent Covalent Binding of [ 3 H]Paroxetine to Human Liver Microsomes and S-9 Fractions: Identification of an Electrophilic Quinone Metabolite of Paroxetine

Zhao, Sabrina X., Dalvie, Deepak K., Kelly, Joan M., Soglia, John R., Frederick, Kosea S., Smith, Evan B., Obach, R. Scott, Kalgutkar, Amit S.

Journal:

Chemical Research in Toxicology

Year:

2007

Language:

english

File:

PDF, 225 KB

english, 2007

31

Oxo Substituents Markedly Alter the Phase II Metabolism of α-Hydroxybutenylbenzenes: Models Probing the Bioactivation Mechanisms of Tamoxifen

Ramakrishna, Kornepati V., Fan, Peter W., Boyer, C. Scott, Dalvie, Deepak, Bolton, Judy L.

Journal:

Chemical Research in Toxicology

Year:

1997

Language:

english

File:

PDF, 291 KB

english, 1997

32

Carbamates of (hydroxyphenoxy)methyl heteroaromatic salts as acetylcholinesterase inhibitors and protective agents against organophosphorus compounds

Sundberg, Richard J., Dalvie, Deepak, Cordero, Joehassin, Sabat, Michal, Musallam, H. A.

Journal:

Chemical Research in Toxicology

Year:

1993

Language:

english

File:

PDF, 726 KB

english, 1993

33

Carbamate derivatives of 2-arylimidazo[1,2-a]pyridinium salts as acetylcholinesterase inhibitors and protective agents against organophosphorus compounds

Sundberg, Richard J., Dalvie, Deepak, Cordero, Joehassin, Musallam, H. A.

Journal:

Chemical Research in Toxicology

Year:

1993

Language:

english

File:

PDF, 591 KB

english, 1993

34

A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes

O’Hara, Fionn, Burns, Aaron C., Collins, Michael R., Dalvie, Deepak, Ornelas, Martha A., Vaz, Alfin D. N., Fujiwara, Yuta, Baran, Phil S.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.17 MB

english, 2014

35

Characterization of an unexpected product from a monoamine oxidase B generated 2,3-dihydropyridinium species

Dalvie, Deepak, Zhao, Zhiyang, Castagnoli, Neal

Journal:

Journal of Organic Chemistry

Year:

1992

Language:

english

File:

PDF, 543 KB

english, 1992

36

A Holistic Strategy for Characterizing the Safety of Metabolites through Drug Discovery and Development

Walker, Don, Brady, Joe, Dalvie, Deepak, Davis, John, Dowty, Martin, Duncan, J. Neil, Nedderman, Angus, Obach, R. Scott, Wright, Pat

Journal:

Chemical Research in Toxicology

Year:

2009

Language:

english

File:

PDF, 314 KB

english, 2009

37

Recent Advances in the Applications of Radioisotopes in Drug Metabolism,Toxicology and Pharmacokinetics

Journal:

Current Pharmaceutical Design

Year:

2000

Language:

english

File:

PDF, 245 KB

english, 2000

38

Practical approaches to resolving reactive metabolite liabilities in early discovery

Dalvie, Deepak, Kalgutkar, Amit S., Chen, Weichao

Journal:

Drug Metabolism Reviews

Year:

2015

Language:

english

File:

PDF, 716 KB

english, 2015

39

Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB. O-BK) || Structural Alert and Reactive Metabolite Analysis for the Top 200 Drugs in the US Market by Prescription

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 925 KB

english, 2012

40

X-autosome translocations in amenorrhoea: a report of a three way translocation from Indian Population

Shetty, Dhanlaxmi L., Kadam, Akshay P., Koppaka, Neeraja T., Dalvi, Rupa C., Chavan, Deepak S., Das, Bibu R., Mandava, Swarna

Journal:

Gynecological Endocrinology

Year:

2014

Language:

english

File:

PDF, 480 KB

english, 2014

41

Why do metabolites circulate?

Smith, Dennis A., Dalvie, Deepak

Journal:

Year:

2012

Language:

english

File:

PDF, 2.21 MB

english, 2012

42

A Comprehensive Listing of Bioactivation Pathways of Organic Functional Groups

Kalgutkar, Amit, Gardner, Iain, Obach, R., Shaffer, Christopher, Callegari, Ernesto, Henne, Kirk, Mutlib, Abdul, Dalvie, Deepak, Lee, Jae, Nakai, Yasuhiro, O'Donnell, John, Boer, Jason, Harriman, Shaw

Journal:

Current Drug Metabolism

Year:

2005

Language:

english

File:

PDF, 483 KB

english, 2005

43

[ACM Press the 2004 ACM SIGKDD international conference - Seattle, WA, USA (2004.08.22-2004.08.25)] Proceedings of the 2004 ACM SIGKDD international conference on Knowledge discovery and data mining - KDD '04 - Adversarial classification

Dalvi, Nilesh, Domingos, Pedro, Mausam,, Sanghai, Sumit, Verma, Deepak

Year:

2004

Language:

english

File:

PDF, 210 KB

english, 2004

44

Discovery of 1-{(3R,4R)-3-[5-Chloro-2-(1-methyl-1H-pyrazol-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxymethyl]-4-methoxy-pyrrolidin-1-yl}propenone (PF-06459988), A Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

Cheng, Hengmiao, Nair, Sajiv K, Murray, Brion W., Almaden, Chau, Bailey, Simon, Baxi, Sangita, Behenna, Douglas Carl, Cho-Schultz, Sujin, Dalvie, Deepak, Dinh, Dac M, Edwards, Martin P., Feng, Jun Li,

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 4.17 MB

english, 2016

45

Cytogenetic profile of acute lymphocytic leukemia patients: report of a novel translocation t(4;13) (q21·3; q35) from an Indian population

Ahmad, Firoz, Dalvi, Rupa, Chavan, Deepak, Das, Bibhu Ranjan, Mandava, Swarna

Journal:

Hematology (American Society of Hematology)

Year:

2008

Language:

english

File:

PDF, 220 KB

english, 2008

46

Biotransformation and bioactivation reactions – 2015 literature highlights

Baillie, Thomas A., Dalvie, Deepak, Rietjens, Ivonne M. C. M., Cyrus Khojasteh, S.

Journal:

Drug Metabolism Reviews

Year:

2016

Language:

english

File:

PDF, 2.57 MB

english, 2016

47

Biotransformation and Bioactivation Reactions – 2016 Literature Highlights

Khojasteh, S. Cyrus, Rietjens, Ivonne M.C.M., Dalvie, Deepak, Miller, Grover

Journal:

Drug Metabolism Reviews

Year:

2017

Language:

english

File:

PDF, 1.24 MB

english, 2017

48

Glucuronides as Potential Anionic Substrates of Human Cytochrome P450 2C8 (CYP2C8)

Ma, Yong, Fu, Yue, Khojasteh, S. Cyrus, Dalvie, Deepak, Zhang, Donglu

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 3.20 MB

english, 2017

49

Discovery of a novel and selective Indoleamine 2,3-dioxygenase (IDO-1) inhibitor 3-(5-fluoro-1 H -indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and its characterization as a potential clinical candidate

Crosignani, Stefano, Bingham, Patrick, Bottemanne, Pauline, Cannelle, Hélène, Cauwenberghs, Sandra, Cordonnier, Marie, Dalvie, Deepak, Deroose, Frederik, Feng, Jun Li, Gomes, Bruno, Greasley, Samantha

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.56 MB

english, 2017

50

[Methods and Principles in Medicinal Chemistry] Reactive Drug Metabolites (KALGUTKAR:REACTIVE METAB.) || Dealing with Reactive Metabolite-Positive Compounds in Drug Discovery

Kalgutkar, Amit S., Dalvie, Deepak, Obach, R. Scott, Smith, Dennis A.

Year:

2012

Language:

english

File:

PDF, 291 KB

english, 2012